Studies supporting the low dose theory have repeatedly been judged by independent regulators as unreliable for use in human risk assessment. None of the studies claiming such effects could be reproduced by other scientist teams. Several comprehensive studies that also investigated the question of potential effects of very small levels of BPA on the metabolism and looked at several generations, did not find any such effect. However, numerous studies show that the level of migration of BPA into food and drink that was in contact with BPA-based materials, if any, is far below any safety-based standards set by government bodies such as the European Food Safety Authority (EFSA) or the U.S. Food and Drug Administration (FDA), and such exposure poses no known health risk.

In January 2015, „Based on scientific criteria EFSA’s experts concluded that the available data do not provide evidence that BPA results in non-monotonic dose-response relationships [i.e. low-dose effects] for the health effects considered.“ . This is supported by the recent conclusion of EFSA based on a comprehensive evaluation of the scientific evidence for non-monotonic dose-response of substances for human risk assessment undertaken by the four national authorities of France (ANSES), The Netherlands (RIVM), Austria (AGES) and Sweden (Karolinska Institutet), and published in May 2016: „…..NMDR as a common phenomenon is so far not supported for substances in the area of food safety.”