In recent years, a theory has been advanced claiming that exposure to extremely low doses of certain substances could cause adverse health effects in humans, whereas no effects are seen at higher doses of the same substance. Bisphenol A is often named as an example of this hypothesis.
This "low-dose hypothesis" for bisphenol A (BPA) has been thoroughly tested with a series of comprehensive and carefully conducted studies. These comprehensive studies have been undertaken by governmental bodies, independent laboratories and industry, using accepted test methods and rigorous Good Laboratory Practice (GLP) guidelines.
The weight of scientific evidence provided by these studies clearly supports the safety of BPA-based applications. In no case could the results of the so called "low dose studies" be reproduced. However, the results of comprehensive multigenerational studies using accepted measures and quality protocols provide strong reassurance that there is no basis for human health concerns from exposure to low doses of BPA through intended uses of BPA-based products.
It is no surprise therefore that time and again, the evaluation by independent regulators leads to the conclusion that the low dose theory is not supported by the relevant studies and the weight of the scientific evidence. Most recently, in July 2008, a European Food Safety Authority (EFSA) opinion echoed the Canadian BPA risk assessment comments that studies indicating low-dose effects were "limited in rigor, consistency and biological plausibility."
More information
Home